Based on my experience, and I have a lot of it; I’ve literately played thousands of video games. In every game, no matter what type of game, if you want to play at a high level you will ALWAYS look for these two things.
1. Mobility –The faster you are the less likely you are to be hit. This is better than defense stats/skills. Not to mention you will have the advantage in any type of speed run. This applies to everything, even fighting games in most cases. Top tier characters are more likely than not to have high mobility.
2. Area of effect damage — In my experience single target DPS is not the way to go. Multi target DPS is. It would take to long to explain why [Basically because the amount of time fighting multiple enemies greatly outnumbers instances fighting single targets] just know that I have personally found the amount of time I save is astounding.
There is a “number 3″ if you play FPS games.” You can’t hit what you can’t see” is a common but very true expression. So if you play FPS’s add stealth and tracking abilities (radar and such) to your list of what to look for.
Let me emphasis this again. No matter what game you play these 2 things will always lead to the best results in high level play. This is the conclusion I have come to after playing thousands of games.
As always nothing is absolute. This method is effective 99% of the time.